Michael Almereyda​ and Courtney Stephens combine forces to chronicle the life and times of influential scientist and psychonaut John Lilly (1915–2001). Assembling archival documentation of Lilly’s projects, talks, and interviews; footage gleaned from popular and ephemeral sources; contemporary interviews with surviving collaborators; a cameo by Alejandro Jodorowsky; and narration by Chloë Sevigny, the filmmakers ​create a multifaceted, critical lens through which to view the accomplishments of a revolutionary thinker whose quest to understand the mysteries of the mind—via dolphins, isolation tanks, LSD, ketamine, and more—is woven into the culture and counterculture of the twentieth century.