Despite a “happy ending” tacked on to appease ethics-code administrators, Uncle Harry remains a strange affair, indeed. George Sanders plays John “Uncle Harry” Quincey, whose mild-mannered surface barely hides a lifetime of chafing at the bit under the constant attentions of his two sisters. When they contrive to thwart his marriage to “another woman,” a battle that has been played out for years on a psychological level finally leads to murder. It is possibly a testament to the force of the film's suggestion of unnatural love and sexual frustration that the present ending was attached (causing producer Joan Harrison to quit Universal Studios in protest). An entry in Film Noir: An Encyclopedic Reference to the American Style notes, “Geraldine Fitzgerald's interpretation of Lettie, the possessive sister, is....a monomania that ranks with the most severe depicted in film noir....” But what the new ending reveals is that “the most disturbed psyche in the film may actually have been that of the protagonist....”